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KMID : 0371420180940010001
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Annals of Surgical Treatment and Research
2018 Volume.94 No. 1 p.1 ~ p.7
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Evaluation of a polyurethane foam dressing impregnated with 3% povidone-iodine (Betafoam) in a rat wound model
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Lee Jin-Won
Song Kyo-Young
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Abstract
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Purpose: The purpose of this study was to evaluate the efficacy of Betafoam in terms of wound healing and safety.
Methods: Fifty-four male adult Sprague-Dawley rats (weight, 200?250 g) were used in the study. Full-thickness skin defects were created on the back of each rats. The rats were assigned to 6 groups according to the type of wound dressing used (n = 9 for each group): Betafoam, Allevyn-Ag, Mepilex-Ag, Medifoam silver, Polymem-Ag, and gauze. The wound size, histological findings, and amount of DNA on the changed dressings for each group were analyzed and compared.
Results: All groups showed an effective decrease in wound size. However, the differences between Betafoam and the other dressings were statistically significant on day 14 (P < 0.05). The number of newly generated blood vessels in the Betafoam group was significantly higher than in the gauze, Allevyn-Ag, and Medifoam silver groups (P < 0.001). In the Betafoam group, the proportion of collagen deposition was highest and showed a significantly superior arrangement of collagen fibers compared with the gauze, Allevyn-Ag, Mepilex-Ag, and Medifoam silver groups. The total content of the remaining DNA counts of the exchanged dressings were significantly lower in the Betafoam group than the others.
Conclusion: Betafoam is effective in wound healing and provides the best performance amongst the various types of dressing materials in terms of re-epithelialization, angiogenesis, collagen deposition, and tissue invasion.
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KEYWORD
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Polyurethane foam, Wound healing, Povidone-iodine, In vivo
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